These features, in combination with the well-established SP and Q ligands, make Capto SP ImpRes and Capto Q ImpRes an excellent choice for reliable intermediate purification and polishing in a commercial setting.
The ligand of Capto SP ImpRes is a sulfonate group while the ligand of Capto Q ImpRes is a quaternary amine group (Fig 2).Ĭapto ImpRes media are based on a high-flow agarose base matrix with good pressure/flow properties (Fig 3) and a small bead size (approx. The strong ion exchange ligand groups of Capto SP ImpRes (left) and Capto Q ImpRes (right) are well established in large-scale purifications.Ĭhromatography media characteristics Ionic groups and base matrixCapto SP ImpRes and Capto Q ImpRes are strong cation and strong anion exchangers, respectively. Capto SP ImpRes and Capto Q ImpRes extend the well-established Capto platform to include high-resolution media for late intermediate purification and polishing.įig 2. Security of supply and comprehensive regulatory supportįig 1. Higher manufacturing productivity enables improved process economy High-throughput purifications easy to optimize and scale up High-resolution intermediate purification and polishing based on the well-established Capto platform with traditional ligandsįlexible process design due to large operational window of flow rates and bed heights
Key benefits of Capto SP ImpRes and Capto Q ImpRes include: Based on the well-established Capto base matrix and with traditional ionic group ligands, they provide many opportunities for improved productivity and straightforward process development. The ability to run at higher flow rates and higher bed heights also increases flexibility in process design.Ĭapto SP ImpRes and Capto Q ImpRes are BioProcess chromatography media developed for large-scale purification of biopharmaceutical proteins. Both chromatography media (resins) are part of an expanded high-resolution platform based on the high-flow agarose Capto product line.īy combining the high-flow characteristics of Capto media with a small particle size, Capto SP ImpRes and Capto Q ImpRes deliver excellent pressure-flow properties with impressive resolution. Data file 28-9837-63 AB Ion exchange chromatographyĬapto SP ImpRes Capto Q ImpResCapto SP ImpRes and Capto Q ImpRes are strong cation and strong anion exchangers for the high-throughput intermediate purification and polishing steps of a wide range of biomolecules.
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